Kate and Gerry McCann have "no doubt" that the Portuguese authorities will eventually reopen the investigation into their daughter Madeleine's disappearance.
Police in Portugal said last week that they had found "no new element" to justify re-launching their inquiry into how the little girl vanished on a family holiday to the Algarve in May 2007.
But the McCanns, speaking on the eve of the fifth anniversary of Madeleine going missing, added their voices to calls from Scotland Yard for the case to be reopened.
Mr McCann, 43, said: "I think the most important thing is that a lot of the investigation opportunities are in Portugal.
"I think it's fairly clear that the case will have to be reopened for those to be pursued adequately.
"We weren't expecting a knee-jerk reaction by any means. This is an ongoing dialogue, and I am sure the investigation will get opened again in due course. I have no doubt about that. It will get reopened."
His 44-year-old wife added: "It's certainly the best way that we're going to find Madeleine, and who took her. If people want to find Madeleine, and want to find the person who took her, then we need the case to be reopened."
The officer leading Scotland Yard's review of the original investigation into Madeleine's disappearance spoke last week of his belief that the case can still be solved and said there is evidence she could still be alive.
Detective Chief Inspector Andy Redwood said the Metropolitan Police would like the case to be reopened, but stressed that the decision was one for Portugal.
Referring to the Portuguese authorities' apparent reluctance to resume their investigation, Mr McCann said: "The only way everyone will be able to move on is for the case to be solved, and that is for Madeleine to be found and the perpetrators brought to justice. Then everyone can move on. Until then it's not going to go away. It can't go away."